In 16th century Japan human illness was commonly believed to be the work of tiny creatures inside the body. Like this guy:
From Pink Tentacle:
Harikikigaki, a book of medical knowledge written in 1568 by a now-unknown resident of Osaka, introduces 63 of these creepy-crawlies and describes how to fight them with acupuncture and herbal remedies. The Kyushu National Museum, which owns the original copy of Harikikgaki, claims the book played an important role in spreading traditional Chinese medicine in Japan.
There are a lot more of these photos on Pink Tentacle.
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